Are macrophages the bad guys in Hodgkin lymphoma?

Volker Diehl

Prognostic models for patients with Hodgkin lymphoma are imperfect and do not allow a precise individualised therapy. A recent gene-expression profiling study, translated into a routine immunohistological test, identified genes of tumour-associated macrophages as being responsible for treatment outcome in patients with Hodgkin lymphoma. If this finding is confirmed by other investigators, it could be a major step towards personalised therapy for patients with Hodgkin lymphoma.

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