This 3-day ESO course is dedicated to clinical, technical and biological innovations in the management of cancer with emphasis on radiation oncology. Hot topics such as single and hypo-fractionated RT, stereotactic brain and body RT, focal RT, particle RT, radiobiology of hypo-fractionation, SBRT and particle RT, the scientific basis of immunotherapy, combination of RT and immunotherapy and targeted therapies, prediction of response and complications, will be discussed. In addition, local Israeli high-tech achievements and innovations in basic and applied cancer research will be presented.