Efforts to find genetic patterns may offer the basis for identifying subgroups of colorectal cancer similar to those now used in breast cancer. Download full article
Progress in treating melanoma has lagged behind many other cancers for decades. But a number of novel approaches are now offering a glimmer of hope. Download full article
This overview looks at the role of age, tumour size, performance status and various predictive and prognostic biomarkers in guiding treatment in newly diagnosed and recurrent disease. Download full article
Robust evidence on the value of neoadjuvant chemotherapy, together with more effective imaging modalities, are opening up new options for gastro-oesophageal cancer. Download full article
Triple negative breast cancers, as a subgroup, are associated with a poor prognosis. But different subtypes within triple negative disease are associated with different outcomes… Download full article
Despite recent progress, pancreatic cancer remains one of the worst cancer diagnoses. Malcolm Moore reviews current management and considers future progress. Download full article
Cancer of unknown primary origin is difficult to manage because, even when the primary can be detected, it behaves differently to cancers of the same type and location that are discovered as primaries. Download full [more]
How can you get the greatest efficacy from neurotoxic drugs without putting patients at risk of acute or chronic damage to their nervous system? Download full article
Thyroid cancers are fairly common, but medical oncology departments generally come across only a small minority of patients with advanced or recurrent disease who respond poorly to standard treatments. Download full article
Better understanding of the different mutations that drive GIST is leading to new paradigms of tailored treatment that break many norms of chemotherapy, especially in management of progression. Download full article
Neutropenia poses a serious threat to patients on chemotherapy – exposes them to infection, leads to delays in treatment and reductions in dose intensity. Awareness of the risks and prompt action are essential. Download full [more]
Early aggressive treatment in patients whose cancer is likely to progress slowly, if at all, causes side-effects and reduces their quality of life for no benefit. Can active surveillance avoid this? Download full article
Many breast cancer therapies affect a woman’s chances of having a child in the future. A growing body of literature is beginning to throw some light on the impact of different treatment options. How can [more]