A recent study has shown that women with BRCA mutations are as likely to achieve local control with breast-conserving treatment as women without mutations, but have increased long-term risk of ipsilateral and contralateral breast cancer. [more]
Results of a recent study indicate that gene expression profiling seems to improve prediction of chemotherapy effect in breast cancer, but methodological caveats remain worrisome. Download full article
Wide variations found between quality of life assessments made by patients and by physicians indicate that patient symptom expression is a complex multidimensional construct. Download full article
A study using hepatic arterial infusion to deliver treatment to colorectal cancer patients with liver metastases is unlikely to lead to wholesale changes in clinical practice, but may spur new studies into the role of [more]
A novel intraperitoneal chemotherapy regimen, trialled in the GOG 172 study, represents a new standard of care for patients with optimally resected stage III ovarian cancer, but should be offered on an individualised basis. Download [more]
Research shows that brain metastasis of breast cancer may occur more often in women with HER2 overexpression. These patients require more aggressive surveillance to identify disease earlier, and new therapies are needed that can overcome [more]
In prostate cancer, a trial comparing conventional- versus high-dose conformal radiotherapy has shown that increasing the dose can improve outcome, with only slight increases in toxicity. Download full article
Use of at least two standard aspirin weekly, for 10 years or more, reduces colon cancer risk in women. Subject to certain caveats, aspirin should be considered for colon cancer prophylaxis. Download full article
A recent analysis of prognostic factors may help identify which follicular and mantle cell lymphoma patients should be excluded from trials of single-agent rituximab therapy. Download full article
Upfront radiation improves progression-free survival and should be offered as an option to patients presenting with low-grade gliomas. Download full article
Lymphatic mapping and sentinel lymph node biopsy is a safe, accurate, and low-morbidity method for the pathologic staging of the regional nodal basin in primary cutaneous melanoma. Download full article
In men with intermediate- to high-risk prostate cancer, radical prostatectomy has been shown to lower the risk of local or systemic progression, and cancer-specific and overall mortality, compared with watchful waiting. Download full article
A new study supports the use of image-guided radiofrequency ablation as a first-line treatment for well-selected cirrhotic patients with early-stage hepatocellular carcinoma. Download full article